Cancer: What’s Eating You? - Part 1

Cancer: What’s Eating You? - Part 1

What Causes Cancer

Cancer has now surpassed heart disease as the number one cause of death for Americans below 85.1 More than 10 million Americans have a history of invasive cancer. Two and one half million Americans will be diagnosed with cancer this year, (one million skin cancers). Cancer will claim over half a million victims this year.2 Why all this cancer? What causes cancer? Can it be avoided? What is the answer for cancer?

As a medical student, I was presented one day with a patient who had a lesion on his lower leg.

“Dr. Clark, examine Mr. Doe’s leg and tell the class your diagnosis.”

The leg was well developed and muscular with clean skin, except an ugly purple raised area.

“Does Mr. Doe have Kaposi’s sarcoma?” I queried, mostly guessing.

“Yes”, came the affirming reply, “And…”
“Oh no,” I thought, “here comes another question.”
“Why do you think Mr. Doe has Kaposi’s sarcoma?” 
To my limited knowledge Kaposi’s sarcoma occurred only in people with AIDS as a consequence of HIV infection, so I asked, “Is the patient HIV positive?”

“No”, came the reply, “but that is a good guess. Mr. Doe has had a kidney transplant and so is on drugs that suppress his immune system.”

This was my awakening to the fact that cancer often arises when the immune system is compromised or suppressed for any reason. It is true that Kaposi’s sarcoma is 1300x more likely to occur in AIDS patients, but lymphoma, (a cancer of the lymph glands throughout the whole body), is 135x more likely, and lung cancer about five times more likely to occur in HIV positive individuals. Just to give you a perspective, ALL cancers are more than twice as common in people whose immune system is disabled or compromised by HIV infection.

Some years ago a series of studies examined how sugar consumption weakens the immune system. Results showed that if a person ate no sugar for 12 hours, each white blood cell could destroy 14 dangerous bacteria. When 24 teaspoons of sugar were eaten (the amount in 2 cans of soda), the white blood cells were so compromised that they could only destroy one bacterium each.3

“But what does the immune system’s ability to eat bacteria have to do with cancer?” you may be asking. A diet high in refined carbohydrates such as sugar, starch, etc. suppresses the immune system, leaving the body unprotected from diseases like cancer. In fact studies show that a person on a high glycemic index diet (high in refined carbohydrates) has a significantly increased risk of acquiring breast,4 prostate,5 colorectal,6 endometrial,7 gastric,8 ovarian,9 or pancreatic1011 cancer. Malnutrition is another cause of a poor immune system. Malnutrition comes in two forms, severe caloric starvation and consumption of empty calories.12 Additionally as people get older their immune systems tend to age, losing the power to fight diseases like cancer.13

Cancer and Viruses

You may be wondering why cancer crops up in the absence of an active immune system. For this puzzle piece, let’s return for a minute to the AIDS/Kaposi’s association. Kaposi’s sarcoma is now known to be the result of a viral infection with either human herpes virus number 8 (HHV-8) or a virus known as Kaposi’s Sarcoma- associated Virus (KSV).14 More and more, infectious agents are being identified in relation to cancer.

So where do people get exposed to these infectious viruses? More and more, animal products such as beef, pork, chicken, turkey, milk and eggs are infected with cancer-causing viruses. Blood of workers in meatpacking plants show evidence of these viruses. These workers have an increased incidence of cancer, including cancers of the lung, mouth and throat, colon, bladder, and kidney.15 Poultry slaughterhouse workers have an increased incidence of throat cancer, liver cancer, lymphoma and leukemia.16

Animal products are known to increase the risk of cancer. The “Adventist Health Study” revealed that prostate cancer was 41% higher in meat eaters, colon cancer17 was 85% higher and ovarian cancer18 was 130% higher than in people who were vegetarians.

The Animal Connection

A study out of Harvard revealed that consumption of meat and dairy products doubles the risk of metastatic prostate cancer. Meat by itself increases metastatic prostate cancer by 66%. Processed meats such as bacon, beef, pork or lamb also increase the risk of metastatic prostate cancer.19

The increased risk of getting cancer from animals is not limited to the consumption of their bodies. In a 4 year case control study in Italy, the consumption of cheese was found to increase the risk of non-Hodgkin lymphoma by 66%.20

Compared to normal breasts, cancerous breasts have 3 times the incidence of infection with bovine leukemia virus, (a virus common in milk and meat). [21] There are other reasons for the meat/cancer association.

One of these is the way meat is prepared for marketing and the way it is cooked. Red meat is associated with increased formation of N- nitroso compounds. These compounds cause DNA damage which results in increased colorectal cancer.22 When people cook meat “well-done” at high temperatures, in an effort to kill all the trichina or “mad cow” disease, they produce mutagenic compounds called heterocyclic amines, which significantly increase the incidence of colorectal cancer.23

Animal foods prepared by frying, broiling or microwaving have been shown to increase the risk of cancer by the formation of toxins called heterocyclic amines.24

Protein, as much as we need it, is safe only in low quantities. Too much protein tends to suppress the immune system. Compared to a low protein diet (5%), a high protein diet (25%) like ours has been shown to both promote tumors and increase metastasis to the liver and lungs.25

Let’s take a minute to look a little closer at dairy products. To begin with, it will help you to know that one of the important parts of your immune system is a white cell called the “natural killer cell”. Milk is immunosuppressive—the more you drink, the worse your natural killer cells will function. What’s more, tripling your milk protein intake triples your cancer risk.26 One of the reasons for this is that cows are fed high protein diets and given growth hormones.27 Cows today produce more milk than they did 100 years ago. Three servings of milk per day significantly increase insulin like growth factor in humans.28 Insulin-like growth factor elevation is linked to cancer of the prostate,29 breast,3031 and lung.32

Hormones and Cancer

At this point it would be well to understand the role of hormones in breast cancer initiation and progression. Anything that increases or prolongs a woman’s exposure to estrogen increases her risk of breast cancer. Estradiol, one of the estrogens, is a potent cell growth stimulator, which is why it also can promote cancer. Thus there is a greater incidence of cancer associated with: early onset of menarche, late menopause, (because the woman is exposed to more years of elevated hormones), hormone replacement therapy, postmenopausal obesity, (because fat cells can produce estrogen) and history of an abortion (because after the loss of the fetus the woman is exposed to the estrogens that were meant to support the pregnancy).33

One often unrecognized source of large doses of growth hormones comes from the use of animal foods. Estradiol is used as a growth promoter in farm animals. Estradiol can actually induce tumors in rats, mice, and hamsters. When levels become artificially elevated in humans there is a corresponding increase in breast and uterine cancer.34 Postmenopausal women with estradiol levels > 9 units (in their entire blood volume) had a 7-fold higher rate of breast cancer than that of women with undetectable levels.35 If a level of nine or greater is bad, you may ask, what would be a source of estradiol that might send my hormones that high? I was interested to find that one American beefsteak had 20 units, one liter of milk 18 units, 2 eggs 13 units, 50 gm of butter 4 units, and 100 gm of cheese 3units!36

Another food that will drive up your hormones is fat. Studies show that high dietary fat intake is associated with elevated serum estrogens and androgens.37 In 1975 Carroll and Khor produced charts showing increased rates of breast, colon, and prostate cancer with increased calorie, fat, and protein intake, country by country. There was a linear relationship between a country’s per capita fat intake and the death rate from cancer.38 Some fats are more dangerous than others. High saturated fat intake triples the risk of dying from prostate cancer.39 Another dangerous fat is the chemically produced fat known as trans-fat. Trans-fat intake has been shown to increases breast,40 prostate,41 and colon cancer.42

My first clinical experience was in gynecology/obstetrics. Besides delivering babies and attending surgeries, much of my time was spent in clinic. Within a few days it became very apparent that from the day a girl came in complaining of discomfort with the onset of menses to the time that a middle aged women came in to tell of her discomfort with hot flashes, we had women on pharmacological doses of hormones.

“And what are the consequences?” you may ask.

In a study of 37,000 women, oral contraceptives significantly increased breast cancer risk.4344 Perimenopausal hormone-replacement therapy with estrogen alone increases the risk of endometrial cancer by 45%.45 And when estrogen is combined with progesterone, breast cancer increases.46 Some replacement hormones are from “natural” sources such as pregnant horse urine. But many are simply chemicals from the laboratory.

Vitamin D and Sunshine

Vitamin D has received a lot of attention recently as an immune stimulator and an anti-cancer agent. Its primary source is ultra-violet light striking the skin.

“But”, you may say, “sun causes skin cancer.”
Here is where the discriminating mind will discern the real cause of skin cancer. In a study of precancerous skin lesions, it was found that people on a high fat diet developed three times the number of lesions compared to those on a low fat diet. Thus, in order to get your anti-cancer vitamin D from the sun, you need also to limit the fat in your diet.47

Weighty Matters

We have been talking about the fat that you eat, but now we need to make mention of the fat that you wear. Fat cells are actually involved in estrogen production. Excess estrogen production in obese women gives them a greater risk of dying with breast cancer.48 Obesity is also a risk factor for pancreatic cancer49, not to mention diabetes and arthritis. Don’t underestimate the contribution of overeating of any kind to the development of cancer.50 When you consume extra food, it tends not only to make you grow, but to make cancer grow also.51

Obesity is usually linked with elevated triglycerides and cholesterol. Elevated cholesterol and triglycerides are associated with significant increases in breast cancer. On the other hand, high levels of HDL, the good cholesterol, significantly decrease breast cancer risk.52

Chemical Toxins

This brings us to out next topic—chemicals in our environment. Chemicals can act like hormones, increasing the risk of cancer.53 Insecticides such as DDT and DDD have hormonal activity54 suppressing the immune system,5556 and increasing the risk of cancer.57 Chemicals tend to accumulate in our environment. Plants can take on small portions of these chemicals. Small creatures eat the plants and then are eaten by larger ones. As you go up the food chain a process called biomagnification occurs. For example sea otters tested for PCBs and DDT showed up to 240x greater levels than that found in their prey.58 The closer to the beginning of the food chain (eat from the garden) the safer your food.

The body is constantly surveying its DNA for damage and making repairs. When DNA damage accumulates, cancer can result. It has been found that lung cancer patients have suppressed DNA repair.59 One commonly encountered substance, which prevents repair of damaged DNA, is caffeine.60 Consequently, two or more cups of coffee per day more than double the risk of ovarian cancer.61 What’s more, when caffeine is combined with a high fat diet, it significantly increases breast cancer risk.62

In this age of scientific discovery, the lung cancer/tobacco connection need hardly be mentioned. But few realize the extent to which other cancers are affected by this poison. Tobacco’s influence can be seen in many malignancies, including cancers of the lip, mouth, throat, voice box, trachea, esophagus, stomach, liver, pancreas, bladder, kidney, cervix, leukemia, colon, skin, and penis.63

Alcohol, a poison to the cells, is involved in 75% of esophageal cancers, 50% of mouth and larynx cancers, 30% of liver cancers, as well as colon, rectal and breast cancer. All totaled, 60,000 deaths per year are related to, not traffic accidents, domestic violence or homicides, but alcohol related cancer.64

New building materials are a common source environmental toxins.

Workers in a newly remodeled office were found
to have increased chemicals in their blood stream and significant decline in their immune function.65 Cancer causing chemicals found indoors include: chloroform, acetaldehyde, formaldehyde, dichlorobenzene, styrene, methylene chloride.66

Another source of environmental toxins is the chemicals added to food as preservatives or flavor enhancers.67 There are many additives to food for which side effects are unknown. Others are questionable or have produced cancer in animals such as BHA,6869 BHT,707172 and potassium bromate,73747576 etc.

In our modern age of plastics more and more of our food is being presented to us in poly containers. Today we get products such as milk, peanut butter, bottled water, apple sauce, and some jams, just to name a few, in plastic containers. It might cause concern to realize that the people making these containers—workers at plastic factories, have 5x the risk of pancreatic and liver cancer.77

A lot of the toxic chemicals in our environment that have carcinogenic potential are halogenated polycarbons. The most common halogens in these substances are fluoride,7879 bromide, or chloride. In these compounds, a halogen such as chloride is attached to a carbon structure, like gasoline, which makes the carbon structure more toxic and poisonous. Should it be any surprise to discover that these halogens are not much better for us if put in our water? A study in Canada revealed that consumption of chlorinated water increases the risk of cancer of the esophagus and stomach and leukemia.8081

When I was a medical student I did research with the General Surgery Department. I was looking at the previous five years of pancreatic cancer patients. To my surprise, none of them was still alive. All had died, and this usually after several surgeries and much pain. The risk of pancreatic cancer is significantly increased by obesity82 and high consumption of: salt, smoked meat, fried food, refined sugar, food with preservatives or additives,83 and coffee.848586 Salt also increases the risk of brain cancer.87 Knowing the risk factors helps us understand what lifestyle changes we can make to improve our chances of avoiding this killer disease.

We all have seen a diesel truck grinding its way up a hill belching black smoke from its exhaust pipe. Products of combustion surround us even in our everyday life (exhaust from cars, gas stoves, etc.) all of which have carcinogenic potential.88 Railroad workers exposed to diesel fumes have a 40% increase in mortality from lung cancer.89

In recent years the phrase “oxidative stress” has become popular. Oxidative stress is merely a measure of the inflammation in the body. Measuring the number of free radicals in the blood often assesses this. Oxidative stress damages DNA that leads to the development of cancer. Chronic inflammation increases the risk of cancer in the gastrointestinal tract.90 For example gastro-esophageal reflux can cause esophagitis, known as Barrett’s Esophagus. In Barrett’s Esophagus, cancer develops because the esophagus is constantly healing itself and just can’t stop healing.91 Cancer is basically cells that are growing or healing out of control.

Melatonin

Melatonin is a protective, anti-cancer hormone and strong antioxidant.92 Light at night suppresses melatonin and increases cancer cell growth rates. Evidence now links exposures to light at night to elevated breast93 and colorectal cancers in night workers.94

Stress

Stress and depression increase cancer because they decrease the immune system’s ability to find and destroy cancer cells.9596 In a ten year follow up study, in which social coping skills, along with the traditional risk factors; smoking, drinking and medical diseases were considered, people with greater stress from poor interpersonal skills had a 40% higher death rate from cancer.97 In another study, divorced or separated women had a 126% higher risk of getting breast cancer, and widowed 100% higher.98 Cancer develops more commonly and grows faster in people with suppressed anger.99 These mental / emotional causes of cancer are some of the most powerful risk factors known to man.

Radiation

One threat to DNA integrity is all the modern sources of radiation. Sources of radiation include radioactive elements, X-rays, gamma rays, microwaves, radio transmitters, electromagnetic fields, ultraviolet light, solar radiation, and nuclear radiation. For example children living within 2 km of an AM radio station have more than double the chances of getting leukemia as those 20 km or more away.100

Another modern source of radiation is the cell phone. Cell phones significantly increase astrocytomas (brain cancer) in the temporal area of the brain (right where you hold your cell phone). There is also an increase in acoustic neurinomas (ear cancer).101

Electric blankets can also be a significant source of radiation. Breast cancer risk associated with electric blanket use increases with the number of years of use, the number of seasons of use, and the length of time of use each night.102 It has been suggested that if you want your bed warmed, turn on the electric blanket or heating pad until the desired temperature is reached, then unplug it before getting into bed.

The relation between breast cancer and electromagnetic field exposure has been the object of much study. For women telephone installers, repairers, and line workers, the risk of breast cancer goes up 117%; for system analysts and programmers 65%; for telegraph and radio operators 40%; and for telephone operators 27%.103

Children are affected by radiation as well. For example the risk of leukemia is elevated in: children whose mothers used an electric blanket or an electric mattress pad during pregnancy; children who themselves use electric blankets or electric mattress pads, hair dryers, video machines in arcades, or video games connected to a television.104

Heavy Metals

Elevated levels of heavy metals including: iron, nickel, chromium, zinc, cadmium, mercury, and lead have been found in tumorous tissues of cancer patients.105 These heavy metals increase oxidative stress and DNA damage, which result in cancer. Mercury, when combined with chloride, produces cancer by acting as a hormone, binding to and activating estrogen receptors.106

Continued in Cancer: What’s Eating You? – Part 2


References

1 Jemal A, Siegel R, Ward E, et. al. Cancer statistics, 2007. CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66.


2 U.S. Cancer Statistics Working Group. United States Cancer Statistics: 2002 Incidence and Mortality. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute; 2005.


3 Kijak. E.; Foust G; Steinman R.R.; Relationship of Blood Sugar Level and Leukocytic Phagacytosis; Southern California Dental Association 1964; 32(9):349-351

4 Augustin LS, Dal Maso L, La Vecchia C, et. al. Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study. Ann Oncol. 2001 Nov;12(11):1533-8.


5 Augustin LS, Galeone C, Dal Maso L, et. al. Glycemic index, glycemic load and risk of prostate cancer. Int J Cancer. 2004 Nov 10;112(3):446-50.


6 Franceschi S, Dal Maso L, Augustin L, et. al. Dietary glycemic load and colorectal cancer risk. Ann Oncol. 2001 Feb;12(2):173-8.


7 Augustin LS, Gallus S, Bosetti C, et. al. Glycemic index and glycemic load in endometrial cancer. Int J Cancer. 2003 Jun 20;105(3):404- 7.


8 Augustin LS, Gallus S, Negri E, La Vecchia C. Glycemic index, glycemic load and risk of gastric cancer. Ann Oncol. 2004 Apr;15(4):581-4.


9 Augustin LS, Polesel J, Bosetti C, et. al. Dietary glycemic index, glycemic load and ovarian cancer risk: a case-control study in Italy. Ann Oncol. 2003 Jan;14(1):78-84.


10 Schernhammer ES, Hu FB, Giovannucci E, et. al. Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts. Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2098-105.


11 Stattin P, Björ O, Ferrari P, et. al. Prospective study of hyperglycemia and cancer risk. Diabetes Care. 2007 Mar;30(3):561-7.


12 Biernat J, Krzysik M. The influence of deficient and excessive dietary energy supply on immune system functioning. Przegl Lek. 2005;62(8):818-20.


13 Bozzetti F. Nutritional issues in the care of the elderly patient. Crit Rev Oncol Hematol. 2003 Nov;48(2):113-21.


14 Dictor M, Rambech E, Way D, et. al. Human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus) DNA in Kaposi’s sarcoma lesions, AIDS Kaposi’s sarcoma cell lines, endothelial Kaposi’s sarcoma simulators, and the skin of immunosuppressed patients. Am J Pathol. 1996 Jun;148(6):2009-16.


15 Johnson ES, Dalmas D, Noss J, et. al. Cancer mortality among workers in abattoirs and meatpacking plants: an update. Am J Ind Med. 1995 Mar;27(3):389-403.


16 Johnson ES, Shorter C, Rider B, Jiles R. Mortality from cancer and other diseases in poultry slaughtering/processing plants. Int J Epidemiol. 1997 Dec;26(6):1142-50.


17 Singh PN, Fraser GE. Dietary risk factors for colon cancer in a low-risk population. Am J Epidemiol. 1998 Oct 15;148(8):761-74.


18 Kiani F, Knutsen S, Singh P, Ursin G, Fraser G. Dietary risk factors for ovarian cancer: the Adventist Health Study (United States). Cancer Causes Control. 2006 Mar;17(2):137-46.


19 Michaud DS, Augustsson K, Rimm EB, et. al. A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control. 2001 Aug;12(6):557-67.


20 Talamini R, Polesel J, Montella M, et. al. Food groups and risk of non-Hodgkin lymphoma: a multicenter, case-control study in Italy. Int J Cancer. 2006 Jun 1;118(11):2871-6.


21 Gertrude Buehring , Ph.D. Symposium Abstract (2005) California Breast Cancer Research Program of the University of California, Grant 6PB-0075 http://www.cbcrp.org/research/PageGrant.asp?grant_id=1815


22 Lewin MH, Bailey N, Bandaletova T, et. al. Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk. Cancer Res. 2006 Feb 1;66(3):1859-65.


23 Sinha R, Kulldorff M, Chow WH, et. al. Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62.


24 Taghavi N, Yazdi I. Type of food and risk of oral cancer. Arch Iran Med. 2007 Apr;10(2):227-32.


25 Li C, Bai X, Wang S, Tomiyama-Miyaji C, et. al. Immunopotentiation of NKT cells by low-protein diet and the suppressive effect on tumor metastasis. Cell Immunol. 2004 Sep-Oct;231(1-2):96-102.


26 Bell RC, Golemboski KA, Dietert RR, Campbell TC. Long-term intake of a low-casein diet is associated with higher relative NK cell cytotoxic activity in F344 rats. Nutr Cancer. 1994;22(2):151-62.


27 Epstein SS. Unlabeled milk from cows treated with biosynthetic growth hormones: a case of regulatory abdication. Int J Health Serv. 1996;26(1):173-85.


28 Heaney RP, McCarron DA, Dawson-Hughes B, et. al. Dietary changes favorably affect bone remodeling in older adults. J Am Diet Assoc. 1999 Oct;99(10):1228-33.


29 Chan JM, Stampfer MJ, Giovannucci E, et. al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science. 1998 Jan 23;279(5350):563-6.


30 Hankinson SE, Willett WC, Colditz GA, et. al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998 May 9;351(9113):1393-6.


31 Frittitta L, Cerrato A, Sacco MG, et. al. The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice. Breast Cancer Res Treat. 1997 Sep;45(2):141-7.


32 Yu H, Spitz MR, Mistry J, et. al. Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst. 1999 Jan 20;91(2):151-6.


33 Russo IH, Russo J. Role of hormones in mammary cancer initiation and progression. J Mammary Gland Biol Neoplasia. 1998 Jan;3(1):49-61.


34 Liehr JG. Is estradiol a genotoxic mutagenic carcinogen? Endocr Rev. 2000 Feb;21(1):40-54.


35 Cummings SR, Duong T, Kenyon E, et. al. Serum estradiol level and risk of breast cancer during treatment with raloxifene. JAMA. 2002 Jan 9;287(2):216-20.


36 Daxenberger A, Ibarreta D, Meyer HH. Possible health impact of animal oestrogens in food. Hum Reprod Update. 2001 May- Jun;7(3):340-55.


37 Nagata C, Nagao Y, Shibuya C, et. al. Fat intake is associated with serum estrogen and androgen concentrations in postmenopausal Japanese women. J Nutr. 2005 Dec;135(12):2862-5.


38 Carroll KK, Khor HT. Dietary fat in relation to tumorigenesis. Prog Biochem Pharmacol. 1975;10:308-53.


39 Fradet Y, Meyer F, Bairati I, et.al. Dietary fat and prostate cancer progression and survival. Eur Urol. 1999;35(5-6):388-91.


40 Kohlmeier L, Simonsen N, van ‘t Veer P, et.al. Adipose tissue trans fatty acids and breast cancer in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Cancer Epidemiol Biomarkers Prev. 1997 Sep;6(9):705-10.


41 King IB, Kristal AR, Schaffer S, et. al. Serum trans-fatty acids are associated with risk of prostate cancer in beta-Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):988-92.


42 Slattery ML, Benson J, Ma KN, et. al. Trans-fatty acids and colon cancer. Nutr Cancer. 2001;39(2):170-5.


43 Newcomer LM, Newcomb PA, Trentham-Dietz A, et. al. Oral contraceptive use and risk of breast cancer by histologic type. Int J Cancer. 2003 Oct 10;106(6):961-4.


44 Hemminki E, Luostarinen T, Pukkala E, et. al. Oral contraceptive use before first birth and risk of breast cancer: a case control study. BMC Womens Health. 2002 Aug 5;2(1):9.


45 Beral V, Bull D, Reeves G, et. al. Endometrial cancer and hormone-replacement therapy in the Million Women Study. Lancet. 2005 Apr 30-May 6;365(9470):1543-51.


46 Tworoger SS, Missmer SA, Barbieri RL, et. al. Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones. J Natl Cancer Inst. 2005 Apr 20;97(8):595-602.


47 Black HS, Herd JA, Goldberg LH, et al. Effect of a low-fat diet on the incidence of actinic keratosis. N Engl J Med. 1994 May 5;330(18):1272-5.


48 Donegan WL, Johnstone MF, Biedrzycki L. Obesity, estrogen production, and tumor estrogen receptors in women with carcinoma of the breast. Am J Clin Oncol. 1983 Feb;6(1):19-24.


49 Silverman DT, Swanson CA, Gridley G, et.al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. J Natl Cancer Inst. 1998 Nov 18;90(22):1710-9.


50 Chang SC, Ziegler RG, Dunn B, Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):334-41.


51 Slattery ML, Caan BJ, Potter JD, et. al. Dietary energy sources and colon cancer risk. Am J Epidemiol. 1997 Feb 1;145(3):199-210.


52 Ray G, Husain SA. Role of lipids, lipoproteins and vitamins in women with breast cancer. Clin Biochem. 2001 Feb;34(1):71-6.


53 Aschengrau A, Coogan PF, Quinn M, et. al. Occupational exposure to estrogenic chemicals and the occurrence of breast cancer: an exploratory analysis. Am J Ind Med. 1998 Jul;34(1):6-14.


54 Klotz DM, Beckman BS, Hill SM, et. al. Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays. Environ Health Perspect. 1996 Oct;104(10):1084-9.


55 Koner BC, Banerjee BD, Ray A. Organochlorine pesticide-induced oxidative stress and immune suppression in rats. Indian J Exp Biol. 1998 Apr;36(4):395-8.


56 Svensson BG, Hallberg T, Nilsson A, et. al. Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int Arch Occup Environ Health. 1994;65(6):351-8.


57 Güttes S, Failing K, Neumann K, et. al. Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch Environ Contam Toxicol. 1998 Jul;35(1):140-7.


58 Kannan K, Kajiwara N, Watanabe M, et. al. Profiles of polychlorinated biphenyl congeners, organochlorine pesticides, and butyltins in southern sea otters and their prey. Environ Toxicol Chem. 2004 Jan;23(1):49-56.


59 Wu X, Roth JA, Zhao H, et. al. Cell cycle checkpoints, DNA damage/repair, and lung cancer risk. Cancer Res. 2005 Jan 1;65(1):349-57.

60 Sarkaria JN, Busby EC, Tibbetts RS, et. al. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 1999 Sep 1;59(17):4375-82.


61 Trichopoulos D, Papapostolou M, Polychronopoulou A. Coffee and ovarian cancer. Int J Cancer. 1981 Dec;28(6):691-3.


62 Minton JP, Abou-Issa H, Foecking MK, Sriram MG.Caffeine and unsaturated fat diet significantly promotes DMBA-induced breast cancer in rats. Cancer. 1983 Apr 1;51(7):1249-53.


63 Newcomb PA, Carbone PP. The health consequences of smoking. Cancer. Med Clin North Am. 1992 Mar;76(2):305-31.


64 Maxcy-Rosenau-Last Public Health & Preventive Medicine,13 ed. 1992 p.816.


65 Baj Z, Majewska E, Zeman K, et. al. The effect of chronic exposure to formaldehyde, phenol and organic chlorohydrocarbons on peripheral blood cells and the immune system in humans. J Investig Allergol Clin Immunol. 1994 Jul-Aug;4(4):186-91.

66 Sax SN, Bennett DH, Chillrud SN, et. al. A cancer risk assessment of inner-city teenagers living in New York City and Los Angeles. Environ Health Perspect. 2006 Oct;114(10):1558-66.


67 Ito N, Fukushima S, Shirai T, et. al. Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis. IARC Sci Publ. 1984;(56):399-407.


68 Ito N, Fukushima S, Tsuda H. Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants. Crit Rev Toxicol. 1985;15(2):109-50.


69 National Toxicology Program. Butylated hydroxyanisole (BHA). Rep Carcinog. 2002;10:40-2.


70 Umemura T, Kodama Y, Hioki K, et. al. Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis. J Cancer Res Clin Oncol. 2001 Oct;127(10):583-90.


71 Thompson JA, Bolton JL, Malkinson AM. Relationship between the metabolism of butylated hydroxytoluene (BHT) and lung tumor promotion in mice. Exp Lung Res. 1991 Mar-Apr;17(2):439-53.


72 Wurtzen G, Olsen P. Chronic study on BHT in rats. Food Chem Toxicol. 1986 Oct-Nov;24(10-11):1121-5.


73 Shiao YH, Kamata SI, Li LM, et. al. Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors. Cancer Lett. 2002 Dec 10;187(1-2):207-14.


74 Crosby LM, Morgan KT, Gaskill B, Origin and distribution of potassium bromate-induced testicular and peritoneal mesotheliomas in rats. Toxicol Pathol. 2000 Mar-Apr;28(2):253-66.


75 DeAngelo AB, George MH, Kilburn SR, et. al. Carcinogenicity of potassium bromate administered in the drinking water to male B6C3F1 mice and F344/N rats. Toxicol Pathol. 1998 Sep-Oct;26(5):587-94.


76 Kurokawa Y, Maekawa A, Takahashi M, et. al. Toxicity and carcinogenicity of potassium bromate—a new renal carcinogen. Environ Health Perspect. 1990 Jul;87:309-35.


77 Byren D, Engholm G, Englund A, Westerholm P. Mortality and cancer morbidity in a group of Swedish VCM and PCV production workers. Environ Health Perspect. 1976 Oct;17:167-70.


78 Takahashi K, Akiniwa K, Narita K. Regression analysis of cancer incidence rates and water fluoride in the U.S.A. based on IACR/IARC (WHO) data (1978-1992). International Agency for Research on Cancer. J Epidemiol. 2001 Jul;11(4):170-9.


79 Tohyama E. Relationship between fluoride concentration in drinking water and mortality rate from uterine cancer in Okinawa prefecture, Japan. J Epidemiol. 1996 Dec;6(4):184-91.


80 Kasim K, Levallois P, Johnson KC, et. al. Chlorination disinfection by-products in drinking water and the risk of adult leukemia in Canada. Am J Epidemiol. 2006 Jan 15;163(2):116-26. Epub 2005 Nov 30.


81 Zoeteman BC, Hrubec J, de Greef E, Kool HJ. Mutagenic activity associated with by-products of drinking water disinfection by chlorine, chlorine dioxide, ozone and UV-irradiation. Environ Health Perspect. 1982 Dec;46:197-205.


82 Larsson SC, Orsini N, Wolk A. Body mass index and pancreatic cancer risk: A meta-analysis of prospective studies. Int J Cancer. 2007 May 1;120(9):1993-8.


83 Ghadirian P, Baillargeon J, Simard A, Perret C. Food habits and pancreatic cancer: a case-control study of the Francophone community in Montreal, Canada. Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):895-9.


84 Porta M, Malats N, Guarner L, et. al. Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group. J Epidemiol Community Health. 1999 Nov;53(11):702-9.


85 Benarde MA, Weiss W. Coffee consumption and pancreatic cancer: temporal and spatial correlation. Br Med J (Clin Res Ed). 1982 Feb 6;284(6313):400-2.


86 MacMahon B, Yen S, Trichopoulos D, et. al. Coffee and cancer of the pancreas. N Engl J Med. 1981 Mar 12;304(11):630-3.


87 Hu J, La Vecchia C, Negri E, et. al. Diet and brain cancer in adults: a case-control study in northeast China. Int J Cancer. 1999 Mar 31;81(1):20-3.


88 Behera D, Balamugesh T. Indoor air pollution as a risk factor for lung cancer in women. J Assoc Physicians India. 2005 Mar;53:190-2.


89 Garshick E, Laden F, Hart JE, et. al. Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect. 2004 Nov;112(15):1539-43.


90 Gasche C, Chang CL, Rhees J, et. al. Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res. 2001 Oct 15;61(20):7444-8.


91 Souza RF, Morales CP, Spechler SJ. Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett’s oesophagus. Aliment Pharmacol Ther. 2001 Aug;15(8):1087-100.


92 Schernhammer ES, Hankinson SE. Urinary melatonin levels and breast cancer risk. J Natl Cancer Inst. 2005 Jul 20;97(14):1084-7


93 Schernhammer ES, Laden F, Speizer FE, et al. Rotating night shifts and risk of breast cancer in women participating in the nurses’ health study. J Natl Cancer Inst. 2001 Oct 17;93(20):1563-8.


94 Pauley SM. Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue. Med Hypotheses. 2004;63(4):588-96.


95 Reiche EM, Morimoto HK, Nunes SM. Stress and depression-induced immune dysfunction: implications for the development and progression of cancer. Int Rev Psychiatry. 2005 Dec;17(6):515-27.


96 Reiche EM, Nunes SO, Morimoto HK. Stress, depression, the immune system, and cancer. Lancet Oncol. 2004 Oct;5(10):617-25.


97 Eysenck HJ. Personality, stress and cancer: prediction and prophylaxis. Br J Med Psychol. 1988 Mar;61 ( Pt 1):57-75.


98 Lillberg K, Verkasalo PK, Kaprio J, et. al. Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003 Mar 1;157(5):415-23.


99 Thomas SP, Groer M, Davis M, et. al. Anger and cancer: an analysis of the linkages. Cancer Nurs. 2000 Oct;23(5):344-9.


100 Ha M, Im H, Lee M, et. al. Radio-Frequency Radiation Exposure from AM Radio Transmitters and Childhood Leukemia and Brain Cancer. Am J Epidemiol. 2007 Jun 7


101 Hardell L, Mild KH, Carlberg M. Further aspects on cellular and cordless telephones and brain tumours. Int J Oncol. 2003 Feb;22(2):399-407.


102 Zhu K, Hunter S, Payne-Wilks K, et. al. Use of electric bedding devices and risk of breast cancer in African-American women. Am J Epidemiol. 2003 Oct 15;158(8):798-806.


103 Caplan LS, Schoenfeld ER, O’Leary ES, Leske MC. Breast cancer and electromagnetic fields—a review. Ann Epidemiol. 2000 Jan;10(1):31-44.
fn104. Hatch EE, Linet MS, Kleinerman RA, et. al. Association between childhood acute lymphoblastic leukemia and use of electrical appliances during pregnancy and childhood. Epidemiology. 1998 May;9(3):234-45.


105 Ionescu JG, Novotny J, Stejskal V, et. al. Increased levels of transition metals in breast cancer tissue. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:36-9.


106 Wang YD, Chen XY, Wu YM, Xu D. Experiment study on the estrogen-like effect of compounds of mercury, chromium and manganese. Wei Sheng Yan Jiu. 2005 Jan;34(1):49-51.


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